Sample size considerations in the design of cluster randomized trials of combination HIV prevention
نویسندگان
چکیده
منابع مشابه
Sample size considerations in the design of cluster randomized trials of combination HIV prevention.
Background Cluster randomized trials have been utilized to evaluate the effectiveness of HIV prevention strategies on reducing incidence. Design of such studies must take into account possible correlation of outcomes within randomized units. Purpose To discuss power and sample size considerations for cluster randomized trials of combination HIV prevention, using an HIV prevention study in Botsw...
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The rigorous evaluation of the impact of combination HIV prevention packages at the population level will be critical for the future of HIV prevention. In this review, we discuss important considerations for the design and interpretation of cluster randomized controlled trials (C-RCTs) of combination prevention interventions. We focus on three large C-RCTs that will start soon and are designed ...
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BACKGROUND The use of cluster randomized trials (CRTs) is increasing, along with the variety in their design and analysis. The simplest approach for their sample size calculation is to calculate the sample size assuming individual randomization and inflate this by a design effect to account for randomization by cluster. The assumptions of a simple design effect may not always be met; alternativ...
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ژورنال
عنوان ژورنال: Clinical Trials
سال: 2014
ISSN: 1740-7745,1740-7753
DOI: 10.1177/1740774514523351